The Intergovernmental Panel on Climate Change Report 2022 (Sixth Assessment Report: Impacts, Adaptation and Vulnerability) indicates that Africa contributed the least to the greenhouse gas emissions yet is experiencing the most widespread ecological and economic losses due to anthropogenic climate change. The report indicates that due to climate change, agricultural productivity growth has been reduced by 34% since 1961 in Africa making it the worst hit region by climate change. Should global temperatures continue to rise, it is envisaged that climate change impacts such as reduced food production will be exacerbated in Africa. As the United Nations Global Compact, we believe that the African and all global private sector’s climate action and leadership are critical to the transition to a net-zero, resilient future by 2050. This discussion will highlight the impact of climate change on food security and inspire and accelerate collective urgent climate action and adaptation needs in Africa. We will also address some pressing questions and challenges such as: What will be Africa’s cost of inaction to scaling up adaptation efforts?; How can we practically accelerate adaptation and resilience for Africa’s food systems?; What kind of investments are needed for Africa to scale up climate adaptation?